Analytical Data
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Gene name
SCML2
- Application
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Alternative Names
SCML2; SCML2_HUMAN; sex comb on midleg like 2 (Drosophila); Sex comb on midleg like 2; Sex comb on midleg like protein 2; Sex comb on midleg. Drosophila. homolog-like 2; Sex comb on midleg-like protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UQR0
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Expression Region
1-700 aa
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AA Sequence
MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS
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Molecular Weight
77.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SCML2 (Sex Comb on Midleg Like 2) is a member of the Sex Comb on Midleg (SCML) family of proteins, known for their roles in epigenetic regulation and developmental processes. Research into SCML2 has garnered interest due to its unique functions in cellular differentiation and proliferation, particularly in stem cell biology and cancer. SCML2 binds to Polycomb group (PcG) proteins, which are crucial for maintaining the transcriptional repression of target genes during development. This property positions SCML2 as a potential modifier of gene expression patterns, influencing the fate of stem cells and the progression of tumors. Moreover, the study of SCML2 has implications for understanding lineage commitment and cellular memory, contributing to the broader field of epigenetics. Recombinant SCML2 proteins are being produced to explore their biochemical properties, interactions with other regulatory proteins, and potential as therapeutic targets. Furthermore, advances in protein engineering and expression systems have facilitated the investigation of SCML2’s structure-function relationship, paving the way for novel insights into its role in health and disease. Understanding the nuances of SCML2 function may provide critical knowledge for developing innovative strategies for stem cell therapy and cancer treatment, highlighting its significance in both basic and applied biomedical research.
