Analytical Data
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基因名
FOLR2
- Application
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别名
FOLR2；Folate receptor beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14207
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表达区间
19-230aa
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氨基酸序列
CSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVN
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分子量
27.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOLR2, or Folate Receptor 2, is a member of the folate receptor family that plays a crucial role in folate transport and cellular uptake, particularly in the context of cancer biology and development. Unlike its closely related counterpart FOLR1, FOLR2 is predominantly expressed in certain tissues, including the placenta and various tumors, making it a potential target for therapeutic strategies aimed at delivering drugs specifically to cancer cells. Research has shown that FOLR2 can be overexpressed in various malignancies, suggesting its involvement in tumor progression and metastasis. Consequently, the development of FOLR2 recombinant proteins has garnered interest for applications in drug targeting and immunotherapy. These recombinant proteins can be engineered to enhance targeting specificity and reduce off-target effects, potentially improving the efficacy of anticancer therapies. Furthermore, the study of FOLR2 also opens avenues for understanding the mechanisms of folate metabolism in tumor biology, which could lead to novel insights in cancer treatment. As such, ongoing research into FOLR2 recombinant proteins aims to elucidate their biological functions and explore their therapeutic potential, contributing to the advancement of targeted cancer therapies.
