Analytical Data
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Gene name
CD39 / ENTPD1
- Application
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Alternative Names
CD39 / ENTPD1；
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49961
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Expression Region
1-510aa
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AA Sequence
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYG IVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNE IGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLD VVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVP YETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYT HSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFL PPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTS YAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGW TLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFH KPSYFWKDMV
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Molecular Weight
82 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD39, also known as ENTPD1, is an ecto-nucleotide triphosphate diphosphohydrolase that plays a crucial role in regulating the immune response and maintaining tissue homeostasis. This enzyme catalyzes the hydrolysis of extracellular ATP and ADP, thereby modulating purinergic signaling, which is essential for various physiological processes. Elevated levels of ATP in the tumor microenvironment can promote inflammation and immune suppression, while CD39 helps to mitigate these effects by depleting ATP. As such, CD39 has gained significant attention in cancer immunotherapy as a potential target for enhancing antitumor immunity. The development of recombinant CD39 proteins enables researchers to conduct in-depth studies regarding its enzymatic functions, substrate specificity, and interactions with other immune modulatory pathways. Additionally, understanding CD39's role in different pathological conditions, including cancer, autoimmune diseases, and chronic inflammatory disorders, is critical for devising novel therapeutic strategies. By generating recombinant CD39 proteins, scientists aim to elucidate the molecular mechanisms underlying CD39-mediated immune regulation and explore their potential for therapeutic intervention, making it a focal point of contemporary biomedical research.
