Analytical Data
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基因名
CENPL
- Application
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别名
CENPL; C1orf155; ICEN33; Centromere Protein L; CENP-L; Interphase centromere complex Protein 33
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N0S6
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表达区间
1-390aa
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氨基酸序列
MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQGLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTAGACHHTRIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
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分子量
70.1 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPL, or Centromere Protein L, is a crucial component of the centromere and plays a significant role in chromosome segregation during cell division. As a member of the CENP family, CENPL is involved in the formation and maintenance of the centromere structure, ensuring accurate mitosis and meiosis. Dysregulation of CENPL has been linked to various human diseases, including cancer, highlighting its importance in maintaining genomic stability. Research into the recombinant expression of CENPL offers valuable insights into its functional dynamics and interactions with other centromeric proteins. By producing CENPL in vitro using recombinant DNA technology, scientists can study its biochemical properties, structural characteristics, and role in the assembly of the centromere complex. These investigations not only enhance our understanding of fundamental cellular processes but also pave the way for potential therapeutic applications targeting cell division errors associated with diseases. The detailed study of CENPL may also contribute to the development of strategies for cancer treatment by identifying novel targets for intervention. Overall, the research on CENPL recombinant proteins is essential for elucidating the mechanisms underlying chromosome behavior and their implications for human health.
