Analytical Data
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基因名
RPN13
- Application
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别名
RPN13；GP110；Proteasomal ubiquitin receptor ADRM1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16186
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表达区间
2-407aa
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氨基酸序列
TTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
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分子量
58.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPN13, a subunit of the 26S proteasome, plays a crucial role in protein degradation and cellular regulation. It is involved in recognizing ubiquitin-conjugated substrates, facilitating their translocation into the proteasome for degradation. Recent studies have highlighted RPN13's significance not only in maintaining cellular homeostasis but also in various disease processes, including cancer and neurodegenerative disorders. Aberrant expression or mutations in RPN13 can disrupt normal proteasomal function, leading to the accumulation of damaged proteins and impaired cellular functions. Given its pivotal role in the ubiquitin-proteasome system, RPN13 has emerged as a potential therapeutic target. Researchers are exploring RPN13's structure and function to better understand its interactions within the proteasome, which could inform the development of novel treatments aimed at enhancing protein clearance or correcting proteasomal dysfunction. Investigating RPN13 might also provide insights into its role in specific signaling pathways and its implications in disease states, making it a focus of interest in molecular biology and pharmacology.
