Analytical Data
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Gene name
LRRTM4
- Application
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Alternative Names
LRRTM4；Leucine-rich repeat transmembrane neuronal Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VH4-1
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Expression Region
1-424aa
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AA Sequence
MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV SFHK
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRTM4 (Leucine-rich repeat transmembrane protein 4) is a member of the leucine-rich repeat protein family, which plays a critical role in neural development and synaptic function. The study of LRRTM4 has gained traction due to its involvement in synaptic signaling pathways and its potential implications in neurodevelopmental disorders, including autism spectrum disorders and schizophrenia. Recent research suggests that LRRTM4 interacts with presynaptic proteins and is essential for the proper formation and maintenance of excitatory synapses in the central nervous system. Understanding the structure and function of LRRTM4 can provide insights into the molecular mechanisms underlying synaptic plasticity and neurodevelopmental processes. Additionally, as researchers explore the therapeutic potential of targeting LRRTM4 in brain disorders, the production and characterization of recombinant LRRTM4 proteins have become vital for both basic research and translational applications. By investigating its interactions and effects in various model systems, scientists aim to elucidate its precise role in synaptic transmission and neurodevelopment, ultimately contributing to the development of innovative strategies for treating related neurological conditions.
