Analytical Data
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Gene name
CDKL4
- Application
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Alternative Names
CDKL4Cyclin-dependent kinase-like 4; EC 2.7.11.22
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5MAI5
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Expression Region
1-315aa
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AA Sequence
MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN EGRNRRRQQV LPLKS
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Molecular Weight
43.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDKL4 (Cyclin-Dependent Kinase-Like 4) is a serine/threonine kinase that plays a crucial role in cell cycle regulation and neuronal development. Recent studies have highlighted its importance in various cellular processes, including cell proliferation, differentiation, and apoptosis. Mutations or dysregulation of CDKL4 have been linked to several neurodevelopmental disorders, particularly intellectual disabilities and autism spectrum disorders. The protein is predominantly expressed in the brain, where it is involved in synaptic function and neural connectivity. The investigation of CDKL4 recombinant protein has gained traction due to its potential as a therapeutic target. By studying the structure and function of this protein, researchers aim to elucidate its role in neurodevelopmental pathways and identify how its dysfunction may lead to disease. Recombinant CDKL4 protein can be utilized in various assays to assess its enzymatic activity, interactions with other proteins, and effects on cellular signaling pathways. Understanding the mechanisms by which CDKL4 operates may offer insights into its contributions to brain health and disease, paving the way for novel therapeutic strategies for conditions linked to its dysfunction. As such, ongoing research into CDKL4 recombinant protein not only enhances our understanding of fundamental cellular processes but also holds promise for developing interventions for neurodevelopmental disorders.
