Analytical Data
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Gene name
CDADC1
- Application
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Alternative Names
bA103J18.1; CDAC1_HUMAN; CDADC1; cytidine and dCMP deaminase domain containing 1; Cytidine and dCMP deaminase domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BWV3
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Expression Region
1-514aa
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AA Sequence
MKEAGQMQNLESARAGRSVSTQTGSMTGQIPRLSKVNLFTLLSLWMELFPAEAQRQKSQKNEEGKHGPLGDNEERTRVSTDKRQVKRTGLVVVKNMKIVGLHCSSEDLHAGQIALIKHGSRLKNCDLYFSRKPCSACLKMIVNAGVNRISYWPADPEISLLTEASSSEDAKLDAKAVERLKSNSRAHVCVLLQPLVCYMVQFVEETSYKCDFIQKITKTLPDANTDFYYECKQERIKEYEMLFLVSNEEMHKQILMTIGLENLCENPYFSNLRQNMKDLILLLATVASSVPNFKHFGFYRSNPEQINEIHNQSLPQEIARHCMVQARLLAYRTEDHKTGVGAVIWAEGKSRSCDGTGAMYFVGCGYNAFPVGSEYADFPHMDDKQKDREIRKFRYIIHAEQNALTFRCQEIKPEERSMIFVTKCPCDECVPLIKGAGIKQIYAGDVDVGKKKADISYMRFGELEGVSKFTWQLNPSGAYGLEQNEPERRENGVLRPVPQKEEQHQDKKLRLGIH
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Molecular Weight
84.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDADC1, or Cytosolic Double-Stranded RNA-Dependent Protein Kinase, has garnered significant attention in the field of molecular biology due to its essential role in cellular responses to viral infections and its involvement in various physiological processes. As a type of protein kinase, CDADC1 is primarily recognized for its ability to phosphorylate target proteins in response to double-stranded RNA (dsRNA), which is often a byproduct of viral replication. This mechanism is crucial for initiating antiviral responses and regulating immune signaling pathways. The study of CDADC1 recombinant protein has become pivotal for understanding its functional dynamics, particularly in the context of innate immunity and disease states like cancer and autoimmune disorders. Researchers aim to elucidate the structural features and signaling pathways associated with CDADC1, which could reveal valuable insights into therapeutic targets. Enhanced characterization of this protein through recombinant DNA technology allows for the production of large quantities of CDADC1 for in vitro studies, facilitating experiments that explore its enzymatic activity, interaction with other cellular proteins, and impact on viral replication mechanisms. By investigating CDADC1, scientists hope to unlock new avenues for developing antiviral therapies and improving immune responses, highlighting its significance in both basic research and clinical applications. Through a combination of biochemical assays, structural biology techniques, and genetic manipulation, the exploration of CDADC1 and its recombinant forms stands as a promising frontier in understanding host-pathogen interactions and advancing therapeutic strategies in infectious diseases.
