Analytical Data
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基因名
CCRK
- Application
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别名
CAK kinase p42; CAK-kinase p42; CCRK; CDCH; CDK activating kinase p42; CDK-activating kinase p42; cdk20; CDK20_HUMAN; Cell cycle related kinase
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZL9
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表达区间
1-275aa
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氨基酸序列
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKLPCLPIHLSCRFLSV
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分子量
55.99 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCRK (cell cycle-related kinase) is a serine/threonine kinase involved in regulating cell cycle progression and cellular growth. Research into CCRK has gained traction due to its implications in various biological processes and diseases, particularly cancer. CCRK is thought to play a critical role in tumorigenesis by influencing cell cycle dynamics and promoting uncontrolled cell proliferation. Its overexpression has been observed in several types of cancer, making it a potential target for novel therapeutic strategies. Furthermore, studies have revealed that CCRK interacts with key cell cycle regulators, thereby modulating signaling pathways that govern DNA replication and mitosis. Given its critical functions, the biochemical characterization and detailed understanding of CCRK's structure and function as a recombinant protein have become essential for elucidating its role in cancer biology. This research not only paves the way for potential drug development but also enhances our understanding of cell cycle regulation and its aberrations in malignancies.
