Analytical Data
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基因名
CCDC89
- Application
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别名
Bc8 orange-interacting Protein; BOIP; CCD89_HUMAN; Ccdc89; Coiled coil domain containing 89; Coiled-coil domain-containing Protein 89
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N998
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表达区间
1-374aa
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氨基酸序列
MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHLSP
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分子量
70.2 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCDC89 (Coiled-Coil Domain Containing 89) is a protein that plays a crucial role in the formation and maintenance of centrosomes, which are key organelles involved in cell division and the organization of microtubules in eukaryotic cells. Recent studies have highlighted its importance in various cellular processes, including mitosis, cell signaling, and maintaining cellular integrity. Dysfunction or mutations in CCDC89 have been implicated in several diseases, particularly cancer, where abnormal centrosome function can lead to genomic instability and tumor progression. Given its pivotal role in cell cycle regulation, the study of CCDC89 has garnered attention in understanding tumorigenesis and exploring potential therapeutic targets. Researchers have turned to recombinant protein technology to produce CCDC89 in a laboratory setting, allowing for detailed structural and functional analyses. This enables investigations into its molecular interactions, regulatory mechanisms, and role in disease. The recombinant CCDC89 protein serves as a vital tool for elucidating its specific functions in the centrosome cycle and potential implications in oncogenesis, ultimately paving the way for novel strategies in cancer treatment and cell biology research.
