Analytical Data
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基因名
RNF208
- Application
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别名
1110061N23Rik; RGD1565957; RING finger protein 208; RN208_HUMAN; Rnf208; RP23-132N23.11-001
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H0X6
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表达区间
1-261 aa
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氨基酸序列
MPSDPGPEAG SGWPGLLMSC LKGPHVILKM EAMKIVHPEK FPELPAAPCF PPAPRPTPTL APKRAWPSDT EIIVNQACGG DMPALEGAPH TPPLPRRPRK GSSELGFPRV APEDEVIVNQ YVIRPGPSAS AASSAAAGEP LECPTCGHSY NVTQRRPRVL SCLHSVCEQC LQILYESCPK YKFISCPTCR RETVLFTDYG LAALAVNTSI LSRLPPEALT APSGGQWGAE PEGSCYQTFR QYCGAACTCH VRNPLSACSI M
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分子量
27.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF208 is an E3 ubiquitin ligase that plays a crucial role in the regulation of various cellular processes, including protein degradation, DNA repair, and cell cycle progression. This protein is known to mediate the polyubiquitination of target substrates, influencing their stability and function. Research has shown that RNF208 is involved in cancer biology, particularly in the modulation of tumor growth and metastasis, making it a potential biomarker for certain cancers. Understanding the mechanisms by which RNF208 exerts its effects could provide insights into tumorigenesis and may lead to the development of novel therapeutic strategies. Additionally, RNF208 is thought to be implicated in several neurodegenerative diseases, underscoring its importance beyond cancer research. However, the exact molecular pathways and interactions involving RNF208 remain to be fully elucidated. Therefore, the production of recombinant RNF208 protein is essential for conducting detailed biochemical assays and structural analyses, which can further the understanding of its functions and regulatory mechanisms. This research not only highlights RNF208’s potential as a therapeutic target but also contributes to the broader field of ubiquitin-mediated protein regulation in health and disease.
