Analytical Data
-
Gene name
VNN1
- Application
-
Alternative Names
VNN1；Pantetheinase
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O95497
-
Expression Region
22-490aa
-
AA Sequence
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQG AHIIVTPEDAIYGWNFNRDSLYPYLEDIPNPEVNWIPCNNRNRFGQTPVQ ERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGK LVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAV TLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPS KKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYAS SIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSE NIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTR FEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVL TVTLFGRLYEKDWASNASSVDHHHHHH
-
Molecular Weight
53 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VNN1, or Vanin-1, is a member of the vanin gene family that encodes a pantetheinase enzyme, playing a crucial role in the hydrolysis of pantetheine to pantothenic acid and cysteamine. Research into VNN1 has gained traction due to its pivotal involvement in various physiological processes, such as inflammation, oxidative stress, and cellular metabolism. Notably, VNN1 is expressed in a variety of tissues, including the heart, liver, and immune cells, indicating its potential significance in health and disease. Recent studies have highlighted its association with several pathological conditions, including cancer, neurodegeneration, and cardiovascular diseases, suggesting that VNN1 could serve as a biomarker or therapeutic target. The recombinant VNN1 protein has become a focal point for researchers aiming to elucidate its enzymatic functions and regulatory mechanisms, as well as its potential implications in therapeutic strategies. By employing advanced molecular biology techniques, scientists are exploring the structure-function relationship of VNN1, its interaction with various substrates, and its influence on metabolic pathways, thus paving the way for a deeper understanding of its role in human health and disease management. The implications of VNN1 research extend to drug development and precision medicine, making it a valuable area of investigation in current biomedical research.
