Analytical Data
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基因名
VNN1
- Application
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别名
VNN1；Pantetheinase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95497
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表达区间
22-490aa
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氨基酸序列
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQG AHIIVTPEDAIYGWNFNRDSLYPYLEDIPNPEVNWIPCNNRNRFGQTPVQ ERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGK LVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAV TLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPS KKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYAS SIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSE NIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTR FEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVL TVTLFGRLYEKDWASNASSVDHHHHHH
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分子量
53 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VNN1, or Vanin-1, is a member of the vanin gene family that encodes a pantetheinase enzyme, playing a crucial role in the hydrolysis of pantetheine to pantothenic acid and cysteamine. Research into VNN1 has gained traction due to its pivotal involvement in various physiological processes, such as inflammation, oxidative stress, and cellular metabolism. Notably, VNN1 is expressed in a variety of tissues, including the heart, liver, and immune cells, indicating its potential significance in health and disease. Recent studies have highlighted its association with several pathological conditions, including cancer, neurodegeneration, and cardiovascular diseases, suggesting that VNN1 could serve as a biomarker or therapeutic target. The recombinant VNN1 protein has become a focal point for researchers aiming to elucidate its enzymatic functions and regulatory mechanisms, as well as its potential implications in therapeutic strategies. By employing advanced molecular biology techniques, scientists are exploring the structure-function relationship of VNN1, its interaction with various substrates, and its influence on metabolic pathways, thus paving the way for a deeper understanding of its role in human health and disease management. The implications of VNN1 research extend to drug development and precision medicine, making it a valuable area of investigation in current biomedical research.
