Analytical Data
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Gene name
ATF2
- Application
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Alternative Names
ATF2；CREB2；CREBP1；Cyclic AMP-dependent transcription factor ATF-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P39905
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Expression Region
76-211aa
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AA Sequence
KRSPDKQMAV LPRRERNRQA AAANPENSRG KGRRGQRGKN RGCVLTAIHL NVTDLGLGYE TKEELIFRYC SGSCDAAETT YDKILKNLSR NRRLVSDKVG QACCRPIAFD DDLSFLDDNL VYHILRKHSA KRCGCI
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATF2, or Activating Transcription Factor 2, is a member of the basic region-leucine zipper (bZIP) family of transcription factors and plays a crucial role in the regulation of gene expression in response to various stress signals, such as UV radiation and oxidative stress. Its function is essential for cellular stress response, differentiation, and apoptosis. Research has shown that ATF2 is involved in numerous biological processes, including cell cycle regulation and apoptosis, making it a critical target for understanding cancer biology and therapy. The dysregulation of ATF2 has been implicated in several cancers, as it can function as both a tumor suppressor and an oncogene, depending on the cellular context. Given its dual role in tumorigenesis, investigating the structure, function, and interaction of ATF2 through recombinant protein studies is crucial. The expression and purification of recombinant ATF2 proteins allow for detailed biochemical characterization and structural analysis, providing insights into its regulatory mechanisms and potential as a therapeutic target. Furthermore, studying the post-translational modifications and protein interactions of ATF2 in various cellular environments can unveil its complex role in cancer progression and therapeutic resistance, thereby contributing to the development of targeted cancer therapies. Thus, ATF2 recombinant protein research is not only vital for understanding fundamental cellular processes but also holds promise for informing novel treatment strategies in oncology.
