Analytical Data
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Gene name
RNF167
- Application
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Alternative Names
RNF167; LP2254; E3 ubiquitin-protein ligase RNF167; RING finger protein 167; RING-type E3 ubiquitin transferase RNF167; RING105
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H6Y7
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Expression Region
1-350 aa
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AA Sequence
MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV
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Molecular Weight
64.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF167, a member of the RING finger protein family, has garnered interest in recent years due to its potential roles in various biological processes, including cell signaling, immune response, and tumorigenesis. The RING domain is a characteristic feature of these proteins, functioning as an E3 ubiquitin ligase that mediates protein degradation and regulates numerous cellular pathways. Recent studies have suggested that RNF167 may play a crucial role in modulating the immune system, particularly in the context of inflammatory responses and autoimmune diseases. Its expression has been linked to various cancers, prompting investigations into its function as a potential oncogene or tumor suppressor. Furthermore, the characterization of recombinant RNF167 protein is essential for elucidating its biochemical properties and understanding its interactions with other cellular components. Research into RNF167 could pave the way for novel therapeutic strategies, especially in targeting diseases where its dysregulation is implicated. Thus, developing RNF167 recombinant protein is a critical step toward unraveling its biological significance, exploring its potential as a biomarker, and assessing its feasibility as a target for drug development.
