Analytical Data
-
Gene name
ADM
- Application
-
Alternative Names
ADM；AM2；Protein ADM2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P35318
-
Expression Region
95-146aa
-
AA Sequence
YRQSMNNFQG LRSFGCRFGT CTVQKLAHQI YQFTDKDKDN VAPRSKISPQ GY
-
Molecular Weight
38 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADM (Adrenomedullin) is a peptide involved in various physiological processes, including vasodilation, cardiac function, and regulation of blood pressure. Research on ADM and its derivatives has gained momentum due to its potential therapeutic applications, particularly in cardiovascular diseases, sepsis, and organ dysfunction. ADM exerts its effects through specific receptors, leading to the activation of intracellular signaling pathways that promote cell survival and mitigate inflammatory responses. The study of ADM’s role in these pathways has sparked interest in its use as a biomarker for disease severity and prognosis. Additionally, the exploration of ADM recombinants aims to enhance its stability and bioavailability, which could lead to more effective treatment modalities. Understanding the structure-function relationship of ADM and the impact of modifications on its activity is crucial for developing novel therapeutic approaches. Advances in genetic engineering and recombinant DNA technology facilitate the production of ADM proteins, allowing researchers to investigate their efficacy in vitro and in vivo. Overall, the ongoing research on ADM reconstitution not only contributes to a deeper understanding of its physiological roles but also paves the way for innovative interventions in various medical conditions.
