Cat: PA2000-6510

Recombinant Human CCDC59 Protein,GST

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Analytical Data

  • Gene name

    CCDC59

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CCDC59; BR22; TAP26; HSPC128; Thyroid transcription factor 1-associated Protein 26; TTF-1-associated Protein 26; Coiled-coil domain-containing Protein 59; TTF-1-associated Protein BR2

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9P031

  • Expression Region

    1-241aa

  • AA Sequence

    MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C

  • Molecular Weight

    55.1 KDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

CCDC59, or Coiled-Coil Domain Containing 59, is a protein encoded by the CCDC59 gene in humans, and it plays a significant role in various cellular processes, particularly in the context of cilia and flagella formation. Cilia are essential organelles involved in cell signaling, sensory perception, and motility, and their dysfunction can lead to a range of diseases known as ciliopathies. Research into CCDC59 has gained momentum due to its potential involvement in the pathogenesis of these disorders. Studies have indicated that CCDC59 may serve as a structural component in ciliary assembly, influencing the stability and function of cilia. Additionally, given its coiled-coil domain, CCDC59 is believed to interact with other ciliary proteins, mediating protein-protein interactions crucial for ciliary integrity. The recombinant expression of CCDC59 allows for detailed exploration of its structure, function, and interactions within the ciliary environment. Understanding the exact role of CCDC59 in ciliary biology may provide insights into related diseases and potential therapeutic approaches, making it a valuable target for further research in cell biology and genetics.

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