Analytical Data
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Gene name
RACK1
- Application
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Alternative Names
RACK1；GNB2L1；Small ribosomal subunit Protein RACK1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63244
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Expression Region
1-317aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA GYTDNLVRVW QVTIGTR
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RACK1 (Receptor for Activated C Kinase 1) is a multifunctional scaffolding protein that plays a crucial role in various cellular processes, including signaling pathways, cell adhesion, and gene expression. Initially identified as a receptor for activated protein kinase C, RACK1 has since been implicated in the regulation of multiple signaling cascades, such as those mediated by G-protein coupled receptors and integrins. Research has highlighted its involvement in various physiological and pathological processes, including cancer progression, neurodegeneration, and inflammation. RACK1's diverse interactions with a wide range of proteins allow it to serve as a critical coordinator of signal transduction events within cells. Furthermore, it has been shown to affect mRNA translation and stability, linking it to post-transcriptional regulation. Given its integral role in numerous cellular mechanisms, RACK1 has attracted significant interest in biomedical research, aiming to unravel its potential as a therapeutic target in diseases where dysregulated signaling pathways are prevalent. Understanding RACK1's precise functions, interactions, and regulatory mechanisms may provide insights into the underlying causes of various diseases and pave the way for innovative therapeutic strategies. Continued investigations into RACK1 and its recombinant forms are essential for elucidating their roles in cellular dynamics and disease, potentially leading to the development of novel interventions in conditions such as cancer and neurodegenerative disorders.
