Analytical Data
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基因名
RNF113A
- Application
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别名
RNF113A; RNF113; ZNF183; E3 ubiquitin-protein ligase RNF113A; EC 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15541
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表达区间
2-343 aa
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氨基酸序列
AEQLSPGKA VDQVCTFLFK KPGRKGAAGR RKRPACDPEP GESGSSSDEG CTVVRPEKKR VTHNPMIQKT RDSGKQKAAY GDLSSEEEEE NEPESLGVVY KSTRSAKPVG PEDMGATAVY ELDTEKERDA QAIFERSQKI QEELRGKEDD KIYRGINNYQ KYMKPKDTSM GNASSGMVRK GPIRAPEHLR ATVRWDYQPD ICKDYKETGF CGFGDSCKFL HDRSDYKHGW QIERELDEGR YGVYEDENYE VGSDDEEIPF KCFICRQSFQ NPVVTKCRHY FCESCALQHF RTTPRCYVCD QQTNGVFNPA KELIAKLEKH RATGEGGASD LPEDPDEDAI PIT
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分子量
38.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF113A, a member of the RING finger protein family, has garnered research interest due to its potential roles in cellular regulation and signaling pathways. Initially identified through genomic studies, this protein is believed to participate in important cellular processes such as ubiquitination, which is crucial for protein degradation, cell cycle regulation, and stress responses. Preliminary studies suggest that RNF113A may be involved in modulating immune responses and maintaining cellular homeostasis. Its structure, characterized by a RING finger domain responsible for E3 ubiquitin ligase activity, highlights its significance in post-translational modifications of target proteins. Given the pivotal role of ubiquitination in various diseases, including cancer and neurodegenerative disorders, understanding RNF113A's function could unveil new therapeutic targets. Moreover, insights into RNF113A’s interactions and mechanisms may contribute to the broader understanding of the ubiquitin-proteasome system. Investigating RNF113A as a recombinant protein enables researchers to explore its functional properties, interactome, and regulatory mechanisms, thereby providing a foundation for future studies aimed at elucidating its biological significance and potential applications in biomedicine.
