Analytical Data
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基因名
SCCA1/SCCA2
- Application
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别名
SCCA1/SCCA2；SCCA；SCCA1；Serpin B3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29508
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表达区间
1-390aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMNSLSEANTKFMFDLFQQFRKSKENNI FYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDR SGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFY QTSESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLNA IYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQA KVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETR VDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVL HKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTN SILFYGRFSSP
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCCA1 (squamous cell carcinoma antigen 1) and SCCA2 are members of the serine protease inhibitor (serpin) family and are primarily expressed in squamous cell carcinoma (SCC) and other tissues. Their elevated levels in cancerous tissues make them potential biomarkers for tumor diagnosis and prognosis. Research has indicated that SCCA1 and SCCA2 may play a role in modulating the immune response and promoting tumor survival by inhibiting apoptosis in tumor cells. The distinct functions and expression patterns of these two isoforms in cancer biology have sparked significant interest. SCCA1 is known to be associated with tumor progression, while SCCA2 has been implicated in protective mechanisms against stress-induced cell death. The recombinant production of these proteins has enabled detailed studies into their structure, function, and interactions, contributing to our understanding of their potential as therapeutic targets. Furthermore, the investigation of SCCA1 and SCCA2 provides insights into the molecular mechanisms of cancer and the development of novel diagnostic tools, highlighting their relevance in both clinical and research settings.
