Analytical Data
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Gene name
RIT2
- Application
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Alternative Names
GTP binding protein Rit2; GTP binding protein Roc2; GTP-binding protein Rit2; Ras like protein expressed in neurons; Ras like without CAAX 2; Ras like without CAAX protein 2; Ras-like protein expressed in neurons; Ras-like without CAAX protein 2; RIBA; Ric (Drosophila) like; Ric like; Ric like. expressed in neurons; RIN; RIT2; RIT2_HUMAN; ROC2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99578
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Expression Region
1-217 aa
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AA Sequence
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT
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Molecular Weight
24.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIT2, a member of the RAS family of small GTPases, has emerged as a significant player in various cellular processes, including cell proliferation, differentiation, and survival. Research into RIT2 has gained momentum due to its implications in both physiological functions and pathological conditions. It has been implicated in neurodevelopment, neuropsychiatric disorders, and certain cancers. Recent studies have shown that RIT2 plays a critical role in neuronal signaling pathways and synaptic function, making it a potential target for therapeutic interventions in neurodegenerative diseases. Additionally, mutations in the RIT2 gene have been associated with susceptibility to conditions like schizophrenia and type 2 diabetes. Thus, understanding RIT2's structure and function at the molecular level is crucial for unraveling its role in these complex biological processes. The development of recombinant RIT2 protein has facilitated detailed biochemical and biophysical studies, providing insights into its GTP-binding dynamics and interaction with downstream effectors. These investigations are essential for elucidating the mechanistic basis of RIT2's activities within the cell and could pave the way for novel treatment strategies targeting RIT2-related pathologies. Consequently, the study of RIT2 recombinant protein represents a promising avenue for advancing our understanding of both its fundamental biology and its potential as a therapeutic target.
