Analytical Data
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基因名
PROM1
- Application
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别名
PROM1；PROML1；Prominin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43490-2
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表达区间
1-856aa
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氨基酸序列
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAG PIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKIVYYEAGI ILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFA ISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETP EQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSM ATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLV HPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQ GYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAF SVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCG VCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGA NVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQV YSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFL LGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKAN SLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGL LERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEF SISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPAL IFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVM TSPSQH
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分子量
123 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PROM1, or Prominin-1, is a transmembrane glycoprotein that plays a crucial role in various cellular processes, including stem cell maintenance, epithelial cell architecture, and cellular signaling. It is predominantly expressed in stem cells and is associated with the formation of membrane protrusions called microvilli, which are essential for cell-cell interactions and signaling pathways. Research has shown that PROM1 is involved in the regulation of cell proliferation and differentiation, making it a significant marker for various stem cell populations in tissues such as the retina, brain, and hematopoietic system. Dysregulation of PROM1 expression has been linked to several diseases, including cancers and degenerative disorders, highlighting its potential as a therapeutic target. Given its important biological functions, the study of recombinant PROM1 proteins has gained traction in the scientific community. Utilizing recombinant DNA technology, researchers aim to produce and analyze PROM1 protein to better understand its structural properties, interaction with other cellular components, and its role in disease mechanisms. Furthermore, the development of PROM1 targeting therapies holds promise for advancing regenerative medicine and cancer treatment strategies. The ongoing research into recombinant PROM1 not only seeks to elucidate the fundamental biology associated with this protein but also explores its applications in diagnostics and therapeutics, thereby contributing to our understanding of stem cell biology and its implications in health and disease.
