Analytical Data
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Gene name
SUV420H2
- Application
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Alternative Names
SUV420H2；SUV420H2；Histone-lysine N-methyltransferase KMT5C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86Y97
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Expression Region
1-462aa
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AA Sequence
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS ALETFLRQRD LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREADE GLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPADGNAAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG AFRTRPREPA LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH AARVSLHRWG GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY VVRVDLRRLA PAPPATPAPA GTPGPILIPK QALAFAPFSP PKRLRLVVSH GSIDLDVGGE EL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SUV420H2 protein, a histone methyltransferase, has gained significant attention in recent years due to its pivotal role in epigenetic regulation and gene expression. As a member of the Su(var)3-9 family, SUV420H2 is primarily involved in the trimethylation of histone H4 at lysine 20 (H4K20me3), a modification associated with transcriptional repression and chromatin compaction. Dysregulation of SUV420H2 has been linked to various human diseases, including cancer, where altered histone methylation patterns can lead to aberrant gene silencing or activation. Studies have shown that SUV420H2 is essential for maintaining genomic stability and influencing cellular differentiation processes, highlighting its importance in developmental biology. Furthermore, understanding the molecular mechanisms underlying SUV420H2 function can provide insights into potential therapeutic targets for diseases associated with epigenetic alterations. This research area is expanding, as scientists aim to elucidate the precise molecular pathways influenced by SUV420H2 and its interactions with other chromatin-modifying proteins, thereby contributing to the growing field of epigenetics and its implications in health and disease. The ongoing exploration of SUV420H2 and its role in regulating chromatin architecture continues to be a promising frontier in both basic and translational research.
