Analytical Data
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基因名
CROT
- Application
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别名
CROT；COT；Peroxisomal carnitine O-octanoyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKG9
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表达区间
1-87aa
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氨基酸序列
MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWVFVVIIE
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分子量
37.2kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CROT (Carnitine O-acetyltransferase) is a crucial enzyme involved in the metabolism of fatty acids, specifically in the transfer of acetyl groups between carnitine and acyl-CoA. This enzyme plays a significant role in the mitochondrial energy production process, linking fatty acid oxidation to the citric acid cycle. Given the rise in metabolic disorders, including obesity and type 2 diabetes, understanding CROT's function and regulation is increasingly important. Research into CROT recombinant protein has gained traction as it allows for the detailed study of its enzymatic properties, structural characteristics, and interactions with other metabolic pathways. By producing CROT in a recombinant form, scientists aim to elucidate its role in gluconeogenesis and lipid metabolism, potentially leading to novel therapeutic targets. Recent studies have explored CROT's expression patterns, regulatory mechanisms, and its implications in metabolic diseases, highlighting its potential as a biomarker or therapeutic target. Overall, the investigation of CROT recombinant protein represents a significant step toward unraveling the complexities of metabolic regulation and addressing health issues related to energy imbalance.
