Analytical Data
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Gene name
RILPL1
- Application
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Alternative Names
GOSPEL; MGC105128 ; MGC99793; Rab interacting lysosomal protein like 1; Rab-interacting lysosomal-like protein 1; RILP like protein 1; RILP-like protein 1; RILPL 1; rilpl1; RIPL1_HUMAN; RLP1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5EBL4
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Expression Region
1-403 aa
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AA Sequence
MEEERGSALA AESALEKNVA ELTVMDVYDI ASLVGHEFER VIDQHGCEAI ARLMPKVVRV LEILEVLVSR HHVAPELDEL RLELDRLRLE RMDRIEKERK HQKELELVED VWRGEAQDLL SQIAQLQEEN KQLMTNLSHK DVNFSEEEFQ KHEGMSERER QVMKKLKEVV DKQRDEIRAK DRELGLKNED VEALQQQQTR LMKINHDLRH RVTVVEAQGK ALIEQKVELE ADLQTKEQEM GSLRAELGKL RERLQGEHSQ NGEEEPETEP VGEESISDAE KVAMDLKDPN RPRFTLQELR DVLHERNELK SKVFLLQEEL AYYKSEEMEE ENRIPQPPPI AHPRTSPQPE SGIKRLFSFF SRDKKRLANT QRNVHIQESF GQWANTHRDD GYTEQGQEAL QHL
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Molecular Weight
47.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RILPL1 (Rab-interacting lysosomal protein 1) is a member of the RILP (Rab-interacting lysosomal protein) family, which plays a crucial role in lysosomal function and intracellular trafficking. Recent studies have highlighted RILPL1's involvement in various cellular processes, including endocytosis and exocytosis, by interacting with Rab GTPases and facilitating the movement of lysosomes within cells. These interactions are particularly important in maintaining cellular homeostasis and response to stress. Dysregulation of RILPL1 has been implicated in several pathological conditions, including neurodegenerative diseases and certain types of cancer. Consequently, understanding RILPL1's structure and function through the generation of recombinant protein is essential for elucidating its biological roles. Researchers aim to investigate the specific domains responsible for its interactions with Rab proteins and other cellular partners. The recombinant expression of RILPL1 will allow for detailed biochemical and biophysical characterization, paving the way for potential therapeutic strategies that target its function in disease contexts. By elucidating the molecular mechanisms of RILPL1, scientists hope to provide insights into the larger network of lysosomal dynamics and their implications in health and disease.
