Analytical Data
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Gene name
APLP1
- Application
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Alternative Names
APLP1；Amyloid beta precursor like Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51693-1
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Expression Region
1-580aa
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AA Sequence
MGPASPAARG LSRRPGQPPL PLLLPLLLLL LRAQPAIGSL AGGSPGAAEA PGSAQVAGLC GRLTLHRDLR TGRWEPDPQR SRRCLRDPQR VLEYCRQMYP ELQIARVEQA TQAIPMERWC GGSRSGSCAH PHHQVVPFRC LPGEFVSEAL LVPEGCRFLH QERMDQCESS TRRHQEAQEA CSSQGLILHG SGMLLPCGSD RFRGVEYVCC PPPGTPDPSG TAVGDPSTRS WPPGSRVEGA EDEEEEESFP QPVDDYFVEP PQAEEEEETV PPPSSHTLAV VGKVTPTPRP TDGVDIYFGM PGEISEHEGF LRAKMDLEER RMRQINEVMR EWAMADNQSK NLPKADRQAL NEHFQSILQT LEEQVSGERQ RLVETHATRV IALINDQRRA ALEGFLAALQ ADPPQAERVL LALRRYLRAE QKEQRHTLRH YQHVAAVDPE KAQQMRFQVH THLQVIEERV NQSLGLLDQN PHLAQELRPQ IQELLHSEHL GPSELEAPAP GGSSEDKGGL QPPDSKDDTP MTLPKGSTEQ DAASPEKEKM NPLEQYERKV NASVPRGFPF HSSEIQRDEL APAGTGVSRE
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Molecular Weight
62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APLP1 (Amyloid Precursor-Like Protein 1) is a member of the amyloid precursor protein (APP) family, which has gained attention due to its potential roles in neurobiology and its implications in Alzheimer's disease. Research indicates that APLP1 is involved in various cellular processes, including synaptic function, neuronal survival, and the modulation of amyloid-beta production. Unlike its more well-known relative APP, APLP1 has a less understood function, although it is believed to participate in generating neuroprotective signals and promoting neuronal health. The interest in APLP1 has been heightened by studies suggesting that its expression level may influence neurodegenerative disease outcomes, making it a promising target for therapeutic intervention. Protein reconstitution studies have aimed to elucidate the structure-function relationship of APLP1, providing insights into its interaction with other proteins and its role in cellular signaling pathways. Understanding the functional dynamics of APLP1 and its recombined forms could lead to breakthroughs in manipulating its pathways for potential treatments in age-related cognitive decline and Alzheimer’s disease, where amyloid processing and neuroprotective mechanisms are critical. Furthermore, by investigating APLP1 in various model systems, researchers seek to clarify its biological significance and explore its utility in drug development aimed at mitigating neurodegeneration. As the field progresses, the comprehensive study of APLP1 and its recombinant forms could enhance our knowledge of brain health and disease, ultimately contributing to the design of innovative strategies for tackling Alzheimer's and other related neurodegenerative disorders.
