Analytical Data
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基因名
RIC3
- Application
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别名
AYST720; FLJ11608; PRO1385; Protein RIC-3; Resistance to inhibitors of cholinesterase 3 homolog; Resistant to inhibitor of cholinesterase 3; RIC3 acetylcholine receptor chaperone; Ric3; RIC3_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z5B4
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表达区间
1-368 aa
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氨基酸序列
MAYSTVQRVALASGLVLALSLLLPKAFLSRGKRQEPPPTPEGKLGRFPPMMHHHQAHSDGQTPGARFQRSHLAEAFAKAKGSGGGAGGGGSGRGLMGQIIPIYGFGIFLYILYILFKLSKGKTTAEDGKCYTAMPGNTHRKITSFELAQLQEKLKETEAAMEKLFNRVGPNGERAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKRRQETILVDYPDPKELSAEEIAERMGMIEEEESDHLGWESLPTDPRAQEDNSVTSCDPKPETCSCCFHEDEDPAVLAENAGFSADSYPEQEETTKEEWSQDFKDEGLGISTDKAYTGSMLRKRNPQGLE
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分子量
67.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIC3 (Resistance to Inhibition of Cholinergic Receptor 3) is a protein that plays a crucial role in the functioning and regulation of nicotinic acetylcholine receptors (nAChRs), which are pivotal for neurotransmission in the central and peripheral nervous systems. The proper assembly and trafficking of nAChRs are vital for their physiological functions, and RIC3 has been identified as a chaperone that assists in their correct folding and maturation. Studies have shown that RIC3 can enhance the expression of certain nAChR subtypes, which has significant implications for understanding diseases such as Alzheimer's, Parkinson's, and other neurodegenerative disorders linked to cholinergic dysfunction. Furthermore, research into RIC3 has potential therapeutic implications, as modulating its activity could influence neuronal signaling pathways and offer new strategies for pharmacological intervention. Given the growing interest in the biological roles of nAChRs and their association with various pathologies, RIC3 serves as a critical target for further study, illuminating the complex mechanisms underlying receptor assembly and signaling in the nervous system. Understanding the precise molecular interactions and regulatory pathways involving RIC3 could pave the way for novel therapeutic approaches aimed at restoring cholinergic function in neurodegenerative diseases.
