Analytical Data
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Gene name
RIBC1
- Application
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Alternative Names
RIBC1; RIB43A-like with coiled-coils protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N443
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Expression Region
1-379 aa
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AA Sequence
MYNIKQSTDT KEAAAIEARR NREKERQNRF FNVRNRVMGV DVQALNNQVG DRKRREAAER SKEAAYGTSQ VQYDVVVQML EKEEADRTRQ LAKKVQEFRE QKQQLKNGRE FSLWDPGQVW KGLPTYLSYS NTYPGPASLQ YFSGEDLDRD TRLRMQQGQF RYNLERQQQE QQQAKVDENY TDALSNQLRL AMDAQATHLA RLEESCRAAM MCAMANANKA QAAVQAGRQR CERQREQKAN LAEIQHQSTS DLLTENPQVA QHPMAPYRVL PYCWKGMTPE QQAAIRKEQE VQRSKKQAHR QAEKTLDTEW KSQTMSSAQA VLELEEQERE LCAVFQRGLG SFNQQLANEQ KAQQDYLNSV IYTNQPTAQY HQQFNTSSR
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Molecular Weight
44.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIBC1 (Ribosome Initiation and Binding Protein 1) is a crucial protein that plays a significant role in ribosome biogenesis and translation regulation, which are vital processes in cellular growth and function. Recent studies have highlighted RIBC1's involvement in various physiological and pathological contexts, including cancer progression, neurodegenerative diseases, and cellular stress responses. The understanding of RIBC1’s structure and function is essential for elucidating its mechanisms of action and potential roles in disease. Researchers have been investigating RIBC1's interactions with other ribosomal proteins and translation factors, as well as its regulatory mechanisms at both the transcriptional and translational levels. The reconstitution of RIBC1 into recombinant forms has facilitated the exploration of its biological activity and interaction networks, leading to insights into how alterations in its expression or function may contribute to disease states. Comprehensive studies on RIBC1 could pave the way for novel therapeutic strategies aimed at targeting aberrant ribosomal function in various disorders, showcasing its potential as a biomarker for disease progression and a candidate for drug development.
