Analytical Data
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Gene name
VDR
- Application
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Alternative Names
VDR；NR1I1；Vitamin D3 receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11473
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Expression Region
1-427aa
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AA Sequence
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE VFGNEIS
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VDR (Vitamin D Receptor) is a crucial nuclear receptor that mediates the biological effects of vitamin D, a hormone that plays a significant role in calcium homeostasis, bone metabolism, and immune function. Research on VDR has gained traction in recent years due to its implications in various diseases, such as osteoporosis, autoimmune disorders, and certain cancers. The study of recombinant VDR proteins is essential for understanding the receptor's structure-function relationship, its mechanisms of action, and its interactions with ligands and co-regulators. Additionally, recombinant VDR proteins enable the development of targeted therapies and diagnostic tools by providing insights into the receptor's role in cellular signaling pathways and gene regulation. Techniques such as protein expression systems and purification methods allow researchers to produce stable and functional VDR protein variants for structural and functional analyses. The ultimate goal of this research is to leverage the knowledge gained from VDR studies to inform therapeutic strategies that exploit vitamin D's beneficial effects while mitigating its potential adverse effects, broadening the scope of vitamin D-related applications in clinical and health-related fields.
