Analytical Data
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Gene name
RGS18
- Application
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Alternative Names
Regulator of G protein signalling 13; Regulator of G Protein Signalling 18; Regulator of G-protein signaling 18; RGS 18; RGS13; RGS18; RGS18_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NS28
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Expression Region
1-235 aa
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AA Sequence
METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL
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Molecular Weight
27.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS18 (Regulator of G-protein Signaling 18) is a member of the RGS protein family, which plays a critical role in the modulation of G-protein-coupled receptor (GPCR) signaling pathways. These proteins function by accelerating the GTPase activity of Gα subunits, thereby promoting the transition from an active GTP-bound state to an inactive GDP-bound state. This regulatory mechanism is essential for maintaining cellular homeostasis and modulating various physiological responses, including proliferation, differentiation, and apoptosis. Recent studies have highlighted the significance of RGS18 in hematopoiesis and immune responses, particularly in the context of B cell and T cell signaling. Dysregulation of RGS proteins has been implicated in various diseases, including cancer, cardiovascular diseases, and autoimmune disorders. Therefore, the exploration of RGS18’s structure, function, and potential as a therapeutic target has gained momentum. Recombinant RGS18 protein, produced using advanced biotechnological methods, can facilitate in-depth studies of its biological activity and interactions with GPCRs. Understanding the molecular mechanisms by which RGS18 modulates G-protein signaling could provide novel insights into its role in health and disease, paving the way for potential therapeutic strategies aimed at enhancing or inhibiting its function in various pathological conditions.
