Analytical Data
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Gene name
GNAS
- Application
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Alternative Names
GNAS；GNAS1；Neuroendocrine secretory Protein 55
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63092
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Expression Region
1-394aa
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AA Sequence
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE SGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLK EAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHA KALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRC RVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRIST ASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
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Molecular Weight
45.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNAS, or Gs alpha subunit, is a critical component of the G protein-coupled receptor signaling pathways, playing a pivotal role in the transduction of extracellular signals into intracellular responses. Mutations or alterations in the GNAS gene have been implicated in various diseases, most notably, endocrine disorders such as pseudohypoparathyroidism and McCune-Albright syndrome. These conditions arise due to abnormal signaling resulting from dysfunctional GNAS proteins. Research into GNAS recombinant proteins focuses on understanding the structural and functional consequences of these mutations, providing insights into the underlying mechanisms of disease. Moreover, the production of recombinant GNAS proteins allows for the development of targeted therapeutic strategies and the exploration of GNAS interactions within signaling networks. The study of GNAS also extends to its involvement in tumorigenesis, where aberrant signaling may contribute to cancer progression. Hence, investigating GNAS recombinant proteins is essential for advancing our knowledge of signal transduction and developing novel treatment approaches for GNAS-related diseases. This area of research continues to grow, driven by the necessity to elucidate the complexities of G protein signaling and its implications in human health.
