Analytical Data
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基因名
GNAS
- Application
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别名
GNAS；GNAS1；Neuroendocrine secretory Protein 55
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63092
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表达区间
1-394aa
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氨基酸序列
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE SGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLK EAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHA KALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRC RVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRIST ASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
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分子量
45.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNAS, or Gs alpha subunit, is a critical component of the G protein-coupled receptor signaling pathways, playing a pivotal role in the transduction of extracellular signals into intracellular responses. Mutations or alterations in the GNAS gene have been implicated in various diseases, most notably, endocrine disorders such as pseudohypoparathyroidism and McCune-Albright syndrome. These conditions arise due to abnormal signaling resulting from dysfunctional GNAS proteins. Research into GNAS recombinant proteins focuses on understanding the structural and functional consequences of these mutations, providing insights into the underlying mechanisms of disease. Moreover, the production of recombinant GNAS proteins allows for the development of targeted therapeutic strategies and the exploration of GNAS interactions within signaling networks. The study of GNAS also extends to its involvement in tumorigenesis, where aberrant signaling may contribute to cancer progression. Hence, investigating GNAS recombinant proteins is essential for advancing our knowledge of signal transduction and developing novel treatment approaches for GNAS-related diseases. This area of research continues to grow, driven by the necessity to elucidate the complexities of G protein signaling and its implications in human health.
