Analytical Data
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Gene name
RDM1
- Application
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Alternative Names
MGC33977; RAD52 homolog B; RAD52 motif 1; RAD52 motif containing 1; RAD52 motif-containing protein 1; RAD52B; RDM1; RDM1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NG50
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Expression Region
1-284 aa
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AA Sequence
MAELVPFAVP IESDKTLLVW ELSSGPTAEA LHHSLFTAFS QFGLLYSVRV FPNAAVAHPG FYAVIKFYSA RAAHRAQKAC DRKQLFQKSP VKVRLGTRHK AVQHQALALN SSKCQELANY YFGFNGCSKR IIKLQELSDL EERENEDSMV PLPKQSLKFF CALEVVLPSC DCRSPGIGLV EEPMDKVEEG PLSFLMKRKT AQKLAIQKAL SDAFQKLLIV VLESGKIAVE YRPSEDIVGV RCEEELHGLI QVPCSPWKQY GQEEEGYLSD FSLEEEEFRL PELD
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Molecular Weight
31.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RDM1, a protein implicated in DNA damage repair, has garnered significant attention due to its role in maintaining genomic stability. It is particularly vital in the context of homologous recombination, a critical mechanism for repairing double-strand breaks in DNA. Research indicates that RDM1 interacts with various proteins involved in the DNA repair pathway, suggesting its function as a scaffold that orchestrates repair processes. Mutations or dysregulation of RDM1 have been associated with various cancers and genetic disorders, underscoring its importance in tumorigenesis and cellular response to genotoxic stress. The study of RDM1 and its recombinant forms can provide insights into the fundamental mechanisms of DNA repair and its implications in cancer biology. Furthermore, understanding the structure and function of RDM1 could lead to the development of novel therapeutic strategies aimed at enhancing DNA repair mechanisms in cancer cells, potentially improving the efficacy of existing treatments. Hence, research on RDM1 not only contributes to the foundational knowledge of cellular repair mechanisms but also opens new avenues for therapeutic interventions in cancer and other diseases linked to DNA repair dysfunction.
