Analytical Data
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Gene name
CABLES2
- Application
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Alternative Names
CABLES2; C20orf150; CDK5 and ABL1 enzyme substrate 2; Interactor with CDK3 2; Ik3-2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BTV7
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Expression Region
1-478aa
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AA Sequence
MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF FLNNISLDGR PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP QGLLSPTQVP TGLGLDGQRQ RKRVTSQRCS LEFLEDAVGC APAQRTKHTS GSPRHKGLKK THFIKNMRQY DTRNSRIVLI CAKRSLCAAF SVLPYGEGLR ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV SYAKFLYPTN ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE KFPHVKLTLS KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS KQNRKLCAGA CVLLAAKISS DLRKSGVTQL IDKLEERFRF NRRDLIGFEF TVLVALELAL YLPENQVLPH YRRLTQQF
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Molecular Weight
52.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CABLES2, a member of the CABLES family of proteins, has garnered attention due to its involvement in various cellular processes, including cell cycle regulation, apoptosis, and signaling pathways. Initially identified for its role as a regulator of the cyclin-dependent kinase CDK2, CABLES2 has been implicated in key mechanisms associated with cancer progression, particularly in tumor suppression. Research indicates that CABLES2 may function as a molecular bridge linking different signaling pathways, particularly those involving oncogenes and tumor suppressors. Its expression levels and activity appear to be altered in several cancer types, suggesting a potential role as a biomarker or therapeutic target. As a result, understanding CABLES2's structure, interaction networks, and functional implications has become a focal point for researchers aiming to unravel its contribution to cellular homeostasis and tumorigenesis. Recent studies have employed advanced techniques such as CRISPR-Cas9 gene editing, RNA sequencing, and proteomics to elucidate the functional dynamics of CABLES2, ultimately aiming to decode its potential in cancer biology and therapeutic application.
