Analytical Data
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基因名
RDH14
- Application
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别名
RDH14; PAN2; SDR7C4; UNQ529/PRO1072; Retinol dehydrogenase 14; EC 1.1.1.300; Alcohol dehydrogenase PAN2; Short chain dehydrogenase/reductase family 7C member 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HBH5
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表达区间
1-336 aa
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氨基酸序列
MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG ANSGLGRATA AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE PGVSGVGELI VRELDLASLR SVRAFCQEML QEEPRLDVLI NNAGIFQCPY MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK SSAPSRIVVV SSKLYKYGDI NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV TVNVLHPGIV RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK
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分子量
36.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RDH14 (retinol dehydrogenase 14) is a member of the short-chain dehydrogenase/reductase (SDR) family, playing a crucial role in the metabolism of vitamin A and the visual cycle. Understanding RDH14 is essential due to its involvement in various physiological processes and potential linkages to pathological conditions, such as retinal degeneration, cancer, and other metabolic disorders. The protein functions primarily in the oxidation and reduction of retinoids, affecting the availability of retinoic acid, a key signaling molecule in development and differentiation. Research on RDH14 recombinant protein enables scientists to elucidate its enzymatic mechanisms and regulatory pathways. Additionally, studying the structure-function relationship of RDH14 through recombinant techniques facilitates the development of potential therapeutic agents targeting retinoid-related disorders. Moreover, recombinant RDH14 offers valuable insights into enzyme kinetics, substrate specificity, and interactions with cofactors and inhibitors, paving the way for novel interventions in diseases associated with retinoid imbalances. As recombinant protein technology continues to advance, RDH14 stands out as a significant focus for developmental biology and medical research, highlighting its importance in both basic science and clinical applications.
