Analytical Data
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Gene name
RDH14
- Application
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Alternative Names
RDH14; PAN2; SDR7C4; UNQ529/PRO1072; Retinol dehydrogenase 14; EC 1.1.1.300; Alcohol dehydrogenase PAN2; Short chain dehydrogenase/reductase family 7C member 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HBH5
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Expression Region
1-336 aa
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AA Sequence
MAVATAAAVL AALGGALWLA ARRFVGPRVQ RLRRGGDPGL MHGKTVLITG ANSGLGRATA AELLRLGARV IMGCRDRARA EEAAGQLRRE LRQAAECGPE PGVSGVGELI VRELDLASLR SVRAFCQEML QEEPRLDVLI NNAGIFQCPY MKTEDGFEMQ FGVNHLGHFL LTNLLLGLLK SSAPSRIVVV SSKLYKYGDI NFDDLNSEQS YNKSFCYSRS KLANILFTRE LARRLEGTNV TVNVLHPGIV RTNLGRHIHI PLLVKPLFNL VSWAFFKTPV EGAQTSIYLA SSPEVEGVSG RYFGDCKEEE LLPKAMDESV ARKLWDISEV MVGLLK
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Molecular Weight
36.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RDH14 (retinol dehydrogenase 14) is a member of the short-chain dehydrogenase/reductase (SDR) family, playing a crucial role in the metabolism of vitamin A and the visual cycle. Understanding RDH14 is essential due to its involvement in various physiological processes and potential linkages to pathological conditions, such as retinal degeneration, cancer, and other metabolic disorders. The protein functions primarily in the oxidation and reduction of retinoids, affecting the availability of retinoic acid, a key signaling molecule in development and differentiation. Research on RDH14 recombinant protein enables scientists to elucidate its enzymatic mechanisms and regulatory pathways. Additionally, studying the structure-function relationship of RDH14 through recombinant techniques facilitates the development of potential therapeutic agents targeting retinoid-related disorders. Moreover, recombinant RDH14 offers valuable insights into enzyme kinetics, substrate specificity, and interactions with cofactors and inhibitors, paving the way for novel interventions in diseases associated with retinoid imbalances. As recombinant protein technology continues to advance, RDH14 stands out as a significant focus for developmental biology and medical research, highlighting its importance in both basic science and clinical applications.
