Analytical Data
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Gene name
FAM20C
- Application
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Alternative Names
FAM20C；DMP4；Extracellular serine/threonine Protein kinase FAM20C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IXL6
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Expression Region
93-584aa
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AA Sequence
DFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDPAHRPLLRD PGPRRSESPPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRL SPKAAENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRH NPAIEALLHDLSSQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTRE QETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMVNMTKEIRD VTRDKKLWRTFFISPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFL PDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSSHRIL DVMDMTIFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELS ILVPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESLRGDQVAPVLYQPH LEALDRRLRVVLKAVRDCVERNGLHSVVDDDLDTEHRAASAR
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Molecular Weight
66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAM20C, or Family with Sequence Similarity 20 Member C, is an essential enzyme involved in the post-translational modification of proteins, particularly through the phosphorylation of specific serine and threonine residues in proteins. This enzyme plays a critical role in the mineralization of bone and teeth by regulating the secretion of matrix proteins that are vital for the formation of extracellular mineralized matrices. The dysfunction of FAM20C has been linked to various skeletal disorders, including amelogenesis imperfecta and autosomal-dominant hypophosphatemic rickets, highlighting its importance in dental and skeletal health. Recent research has focused on understanding the biochemical pathways and mechanisms through which FAM20C influences mineralization processes. The generation of recombinant FAM20C protein has become increasingly significant for studying its structure-function relationship, enzyme kinetics, and interaction with substrate proteins. By utilizing recombinant technology, researchers aim to elucidate its role in biomineralization and explore potential therapeutic interventions for diseases associated with FAM20C deficiency. Understanding the functional properties of FAM20C at the molecular level may also pave the way for novel strategies in regenerative medicine, particularly in the fields of orthopedics and dentistry. Overall, the investigation of recombinant FAM20C holds promise for advancing our comprehension of mineralization processes and developing targeted therapies for related pathologies.
