Analytical Data
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Gene name
RBM23
- Application
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Alternative Names
CAPERbeta; FLJ10482; MGC4458; PP239; Probable RNA binding protein 23; Probable RNA-binding protein 23; RBM 23; RBM23; RBM23_HUMAN; RNA binding motif protein 23; RNA binding region (RNP1 RRM) containing 4; RNA binding region containing protein 4; RNA-binding motif protein 23; RNA-binding region-containing protein 4; RNPC4; Splicing factor SF2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86U06
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Expression Region
1-439 aa
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AA Sequence
MASDDFDIVI EAMLEAPYKK EEDEQQRKEV KKDYPSNTTS STSNSGNETS GSSTIGETSK KKRSRSHNKS RDRKRSRSRD RDRYRRRNSR SRSPGRQCRH RSRSWDRRHG SESRSRDHRR EDRVHYRSPP LATGYRYGHS KSPHFREKSP VREPVDNLSP EERDARTVFC MQLAARIRPR DLEDFFSAVG KVRDVRIISD RNSRRSKGIA YVEFCEIQSV PLAIGLTGQR LLGVPIIVQA SQAEKNRLAA MANNLQKGNG GPMRLYVGSL HFNITEDMLR GIFEPFGKID NIVLMKDSDT GRSKGYGFIT FSDSECARRA LEQLNGFELA GRPMRVGHVT ERLDGGTDIT FPDGDQELDL GSAGGRFQLM AKLAEGAGIQ LPSTAAAAAA AAAQAAALQL NGAVPLGALN PAALTALSPA LNLASQCFQL SSLFTPQTM
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Molecular Weight
48.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBM23 (RNA-binding motif protein 23) is a nuclear protein that plays a critical role in RNA splicing, regulation, and gene expression. Its involvement in various cellular processes and its association with several diseases, including cancers and neurodegenerative disorders, have garnered significant interest in the research community. Studies have shown that RBM23 interacts with splicing factors and other RNA-binding proteins, highlighting its importance in the regulation of pre-mRNA splicing and mRNA stability. The recombinant expression of RBM23 in heterologous systems allows for a detailed examination of its functional properties and interactions. Such studies are crucial for understanding the mechanistic role of RBM23 in cellular biology and its potential as a therapeutic target. The development of robust protocols for RBM23 protein purification and characterization can facilitate the exploration of its structure-function relationships and provide insights into how mutations or dysregulation of RBM23 contribute to disease pathogenesis. Furthermore, elucidating the role of RBM23 in RNA metabolism may reveal new layers of complexity in post-transcriptional regulation and offer novel strategies for intervention in RNA-related diseases. Overall, the research on RBM23 recombinant protein has the potential to advance our understanding of molecular mechanisms governing gene expression and foster the discovery of innovative therapeutic approaches.
