Analytical Data
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Gene name
XERO1
- Application
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Alternative Names
XERO1；DHNX；Dehydrin Xero 1
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Species
Arabidopsis thaliana
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25863
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Expression Region
1-128aa
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AA Sequence
MESYQNQSGAQQTHQQLDQFGNPFPATTGAYGTAGGAPAVAEGGGLSGMLHRSGSSSSSSSEDDGLGGRRRKKKGITEKIKEKLPGHHDSNKTSSLGSTTTAYDTGTVHHEKKGMMEKIKEKLPGGHH
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Molecular Weight
15.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XERO1, a gene associated with X-linked ichthyosis and specifically linked to the skin barrier function, encodes a protein that plays a critical role in cellular processes, including cell proliferation and differentiation. The study of XERO1 recombinant protein has gained attention due to its implications in understanding various skin disorders and potential therapeutic applications. Research has revealed that mutations or aberrations in the XERO1 gene can lead to significant clinical manifestations, particularly in males, given its X-linked inheritance pattern. As an essential component of the epidermal barrier, XERO1 is involved in keratinocyte function and skin homeostasis. Investigating the recombinant form of this protein allows for detailed exploration of its structural properties and interactions within cellular systems. Additionally, employing recombinant DNA technology to produce XERO1 can facilitate studies aimed at elucidating its functional characteristics and mechanistic pathways. Understanding XERO1's role not only aids in comprehending ichthyosis but also opens avenues for developing targeted therapies and enhancing skin health. Given the rising prevalence of skin conditions linked to genetic factors, this line of research is increasingly significant in dermatology and personalized medicine, paving the way for innovative approaches to treatment and management of skin diseases.
