Analytical Data
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基因名
RPS6KB1
- Application
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别名
RPS6KB1；FRAP；FRAP1；FRAP2；Serine/threonine-Protein kinase mTOR
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8BSK8
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表达区间
1-525aa
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氨基酸序列
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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分子量
62.1kda
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
RPS6KB1, also known as ribosomal protein S6 kinase beta-1, is a serine/threonine kinase that plays a critical role in the regulation of cell growth, proliferation, and survival. This protein is a key component of the mammalian target of rapamycin (mTOR) signaling pathway, which integrates various extracellular signals to promote protein synthesis and cell anabolism. Dysregulation of RPS6KB1 has been implicated in several diseases, including cancer, obesity, and metabolic disorders. Research on RPS6KB1 is essential for understanding its functional mechanisms and its contributions to cellular processes. Additionally, the study of RPS6KB1 as a recombinant protein has various implications; it can facilitate drug development targeting the mTOR pathway and provide insights into therapeutic strategies for diseases associated with RPS6KB1 dysregulation. The recombinant expression of RPS6KB1 enables the examination of its structure, enzymatic activity, and interactions with downstream substrates, providing a basis for elucidating its role in pathophysiology and potential as a biomarker or therapeutic target. Overall, the study of RPS6KB1 and its recombinant form is significant in the context of cellular biology and has far-reaching implications for medical research and treatment development.
