Analytical Data
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Gene name
HOXA1
- Application
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Alternative Names
HOXA1；HOX1F；Homeobox Protein Hox-A1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49639
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Expression Region
1-335aa
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AA Sequence
MDNARMNSFL EYPILSSGDS GTCSARAYPS DHRITTFQSC AVSANSCGGD DRFLVGRGVQ IGSPHHHHHH HHHHPQPATY QTSGNLGVSY SHSSCGPSYG SQNFSAPYSP YALNQEADVS GGYPQCAPAV YSGNLSSPMV QHHHHHQGYA GGAVGSPQYI HHSYGQEHQS LALATYNNSL SPLHASHQEA CRSPASETSS PAQTFDWMKV KRNPPKTGKV GEYGYLGQPN AVRTNFTTKQ LTELEKEFHF NKYLTRARRV EIAASLQLNE TQVKIWFQNR RMKQKKREKE GLLPISPATP PGNDEKAEES SEKSSSSPCV PSPGSSTSDT LTTSH
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXA1 (Homeobox A1) is a critical transcription factor belonging to the HOX gene family, which plays a vital role in embryonic development and the regulation of gene expression. Its involvement in various cellular processes, such as cell differentiation, proliferation, and migration, has garnered significant interest, particularly in the context of developmental biology and cancer research. Mutations or dysregulation of HOXA1 have been implicated in several congenital malformations and malignancies, making it a focal point for therapeutic research. The recombinant expression of HOXA1 protein in various systems allows for the detailed study of its structural and functional characteristics, aiding in the understanding of its role in gene regulation and developmental pathways. Advances in recombinant DNA technology have enabled the production of HOXA1 protein in sufficient quantities, facilitating biochemical assays and structural analyses. The study of HOXA1's interactions with other proteins and its downstream targets can provide insights into the molecular mechanisms underlying its function. Moreover, investigations into HOXA1's potential as a therapeutic target could pave the way for innovative treatments for diseases associated with its aberrant expression. Overall, research on HOXA1 recombinant protein is essential for elucidating its biological significance and may contribute to advancements in regenerative medicine and cancer therapy.
