Analytical Data
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Gene name
RASGEF1C
- Application
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Alternative Names
RASGEF1C; Ras-GEF domain-containing family member 1C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N431
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Expression Region
1-466 aa
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AA Sequence
MPQTLSASDM VTPGSLSPPP TEPTDGEQAG QPLLDGAPSS ASLETLIQHL VPTADYYPEK AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGPKL LQLLAEWTET FPRDFQEEST IGHLKDVVGR IAPCDEAYRK RMHQLLQALH QKLAALRQGP EGLVGADKPI SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC FSDKTSNLEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA IISGMNMSPV SRLKKTWAKV RTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDAS ITHYLYTAPI FSEDGLYLAS YESESPENQT EKERWKALRS SILGKT
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Molecular Weight
52.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASGEF1C, a member of the RAS guanine nucleotide exchange factor (GEF) family, plays a crucial role in modulating RAS signaling pathways, which are pivotal in regulating cellular processes such as growth, differentiation, and survival. This protein facilitates the exchange of GDP for GTP on RAS proteins, thereby activating them and promoting downstream signaling that can lead to oncogenic transformations. The study of RASGEF1C is particularly pertinent given the prevalence of RAS mutations in various cancers, which often result in dysregulated signaling cascades. Understanding the function and regulation of RASGEF1C may provide insights into potential therapeutic targets for cancers driven by RAS pathway abnormalities. Recent research has indicated that RASGEF1C may also have roles beyond traditional RAS signaling, potentially influencing other pathways and cellular events. Consequently, the characterization of RASGEF1C, including its structural properties and interaction with other signaling molecules, is essential for a comprehensive understanding of its biological functions and implications in disease contexts. As such, RASGEF1C represents a promising area of investigation for developing novel cancer therapies and elucidating the complexities of RAS-mediated signaling networks in health and disease.
