Analytical Data
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Gene name
TERF1
- Application
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Alternative Names
TERF1；PIN2；TRBF1；TRF；Telomeric repeat-binding factor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54274
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Expression Region
2-439aa
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AA Sequence
AEDVSSAAP SPRGCADGRD ADPTEEQMAE TERNDEEQFE CQELLECQVQ VGAPEEEEEE EEDAGLVAEA EAVAAGWMLD FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIQA IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYNHMMEKI KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQDKPSG NDVEMETEAN LDTRKSVSDK QSAVTESSEG TVSLLRSHKN LFLSKLQHGT QQQDLNKKER RVGTPQSTKK KKESRRATES RIPVSKSQPV TPEKHRARKR QAWLWEEDKN LRSGVRKYGE GNWSKILLHY KFNNRTSVML KDRWRTMKKL KLISSDSED
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TERF1, also known as telomeric repeat-binding factor 1, is a crucial protein involved in the maintenance and regulation of telomeres, which are the protective caps at the ends of linear chromosomes. Telomeres play a significant role in cellular aging and genomic stability, and the dysfunction of telomere maintenance mechanisms is implicated in various age-related diseases, including cancer. Research on TERF1 has gained momentum due to its essential role in telomere length regulation, protection against chromosomal end degradation, and involvement in the DNA damage response. Recombinant TERF1 protein has been produced to study its functions and interactions at the molecular level. By using recombinant DNA technology, researchers can obtain large quantities of pure TERF1 for biochemical assays, structural studies, and cellular experiments. Investigating the properties of TERF1 and its interactions with other telomere-associated proteins can provide valuable insights into the mechanisms underlying telomere biology and its implications in human health. Understanding the regulatory networks involving TERF1 could also lead to potential therapeutic targets for age-associated diseases and cancer treatment. Thus, the study of recombinant TERF1 protein is not only pivotal for elucidating the fundamental aspects of telomere biology but also holds promise for advancing translational research in regenerative medicine and oncology.
