Analytical Data
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基因名
TFAP2C
- Application
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别名
TFAP2C；Transcription factor AP-2 gamma
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92754
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表达区间
1-450aa
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氨基酸序列
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TFAP2C (Transcription Factor AP-2 Gamma) is a member of the AP-2 family of transcription factors, known for its critical role in regulating gene expression during embryonic development and differentiation. This protein is particularly important in the development of the brain, heart, and various epithelial tissues. Abnormal expression of TFAP2C has been linked to several human diseases, including various cancers, where it can act as an oncogene or a tumor suppressor depending on the context. Researchers have been investigating the mechanisms of TFAP2C in cellular processes such as proliferation, differentiation, and apoptosis. The creation of recombinant TFAP2C proteins is fundamental for studying their structure-function relationships and understanding their molecular interactions. Such recombinant proteins are typically produced in various expression systems, including bacteria, yeast, and mammalian cells, allowing for the assessment of TFAP2C's functional properties in vitro. By employing techniques like co-immunoprecipitation and luciferase reporter assays, researchers can elucidate the pathways regulated by TFAP2C and its downstream targets. Additionally, the role of TFAP2C in epigenetic regulation and its interactions with other transcription factors and co-regulators are being actively explored, making it a significant focus in cancer biology and developmental studies. Overall, the characterization of TFAP2C through recombinant protein studies is vital for uncovering its biological functions and potential therapeutic implications.
