Analytical Data
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基因名
C1GALT1C1
- Application
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别名
HSPC067; 3-galactosyltransferase 2; Beta 1.3 galactosyltransferase 2 ; Beta1.3 galactosyltransferase 2 ; C1Gal T2 ; C1Gal-T2; C1GALT1 specific chaperone 1 ; C1GALT1-specific chaperone 1; C1galt1c1; C1GalT2; C1GLC_HUMAN; C38H2 L1; C38H2 like Protein 1; C38H2-L1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96EU7
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表达区间
1-318aa
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氨基酸序列
MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND
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分子量
60.72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C1GALT1C1, also known as Galactosyltransferase 1, is a key enzyme involved in the biosynthesis of the Tn antigen, a carbohydrate structure associated with various cancers. The study of C1GALT1C1 has gained significant attention due to its role in the aberrant glycosylation of proteins and lipids in tumor cells, which can influence tumor progression, immune evasion, and metastasis. Dysregulated expression of C1GALT1C1 has been implicated in several malignancies, making it a potential biomarker for cancer diagnosis and prognosis. Furthermore, understanding the molecular mechanisms regulating C1GALT1C1 activity could lead to innovative therapeutic strategies that target glycosylation pathways in cancer treatment. Research on recombinant C1GALT1C1 proteins aims to elucidate its structure-function relationships and catalytic mechanisms, providing insights into its biological significance and potential as a target for drug development. By generating and characterizing these recombinant proteins, scientists hope to better understand the enzyme's role in glycan biosynthesis and its implications in tumor biology, ultimately contributing to more effective cancer therapies.
