Analytical Data
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Gene name
JAM1
- Application
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Alternative Names
JAM1；JAM1；JCAM；Junctional adhesion molecule A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y624
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Expression Region
26-238aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGV
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JAM1 (Junctional Adhesion Molecule 1) is a member of the immunoglobulin superfamily and plays a crucial role in various cellular processes, particularly in maintaining tight junction integrity in endothelial cells and epithelial tissues. Increasing evidence has indicated that JAM1 is involved in the regulation of immune responses and inflammation, acting as a crucial mediator in leukocyte adhesion and migration. Its expression can be modulated by various stimuli, linking it to pathological conditions such as cancer, autoimmunity, and cardiovascular diseases. Research has shown that JAM1 interacts with numerous intracellular signaling pathways and other cell adhesion molecules, which further underscores its significance in cellular communication and tissue homeostasis. Given its pivotal role in both normal physiological functions and disease mechanisms, JAM1 has emerged as a potential therapeutic target. Recombinant JAM1 protein is being studied for its utility in elucidating the molecular mechanisms underlying its function, as well as for developing strategies to manipulate its activity in disease contexts. The production and characterization of recombinant JAM1 can provide valuable insights into its structural properties and interactions, paving the way for clinical applications and the development of novel therapeutics aimed at modulating JAM1 activity to restore normal cellular functions in disease states.
