Analytical Data
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Gene name
C16orf72
- Application
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Alternative Names
C16orf72UPF0472 Protein C16orf72
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14CZ0
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Expression Region
1-275aa
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AA Sequence
MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLPPELQEEAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNGLHDVDLNTFISEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRMI
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Molecular Weight
30.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C16orf72, a gene located on chromosome 16, has emerged as a significant focus in neuroscience and genetics due to its association with neurodegenerative diseases, particularly frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The discovery of hexanucleotide repeat expansions in this gene was pivotal, marking a breakthrough in understanding the genetic underpinnings of FTD and ALS. Research indicates that C16orf72 is involved in several cellular processes, including autophagy, neurotransmitter release, and the regulation of RNA metabolism. Its mutation leads to the accumulation of toxic dipeptide-repeat proteins, contributing to neuronal cell death. Investigating the recombinant protein of C16orf72 can provide crucial insights into the molecular mechanisms underlying these diseases, potentially uncovering new therapeutic targets. Moreover, understanding the functional properties of the recombinant C16orf72 protein may elucidate its role in normal physiology and pathological conditions, paving the way for advancements in treatment strategies for associated neurodegenerative disorders.
