Analytical Data
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Gene name
PRV1
- Application
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Alternative Names
CD177; CD177 antigen; CD177 molecule; CD177_HUMAN; HNA-2a; HNA2A; Human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera 1; Polycythemia rubra vera protein 1; PRV-1; PRV1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N6Q3
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Expression Region
22-408 aa
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AA Sequence
LLCQFGTVQ HVWKVSDLPR QWTPKNTSCD SGLGCQDTLM LIESGPQVSL VLSKGCTEAK DQEPRVTEHR MGPGLSLISY TFVCRQEDFC NNLVNSLPLW APQPPADPGS LRCPVCLSME GCLEGTTEEI CPKGTTHCYD GLLRLRGGGI FSNLRVQGCM PQPGCNLLNG TQEIGPVGMT ENCNRKDFLT CHRGTTIMTH GNLAQEPTDW TTSNTEMCEV GQVCQETLLL LDVGLTSTLV GTKGCSTVGA QNSQKTTIHS APPGVLVASY THFCSSDLCN SASSSSVLLN SLPPQAAPVP GDRQCPTCVQ PLGTCSSGSP RMTCPRGATH CYDGYIHLSG GGLSTKMSIQ GCVAQPSSFL LNHTRQIGIF SAREKRDVQP PASQHEGG
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Molecular Weight
46.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRV1, or Proviral integration site for Moloney murine leukemia virus, is a gene initially identified in the context of retroviral integration, which plays a crucial role in various biological processes, particularly in cell growth and differentiation. Recent studies have highlighted its significance in tumor biology and hematopoiesis. Researchers have focused on the recombinant protein PRV1 due to its potential as a biomarker and therapeutic target in certain cancers. By examining its expression patterns and functional roles, scientists aim to elucidate its contribution to oncogenesis and to develop innovative treatment strategies. Additionally, the study of PRV1 recombinant protein may provide insights into the underlying mechanisms of disease progression and resistance to therapies. Advances in recombinant DNA technology have facilitated the production of PRV1 protein, enabling in-depth investigations into its structure and function, and opening new avenues for clinical applications. This research not only enhances our understanding of PRV1's biological roles but also underscores the broader impact of viral integration on human health, highlighting the need for continued exploration of this intriguing protein in cancer research and therapeutic development.
