Analytical Data
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基因名
IGFBP2
- Application
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别名
IGFBP2；IIP45；Migration and invasion-inhibitory Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18065
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表达区间
37-325aa
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氨基酸序列
EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Insulin-like growth factor binding protein 2 (IGFBP2) is a key regulator of insulin-like growth factor (IGF) signaling, which plays a crucial role in cellular growth, differentiation, and survival. The aberrant expression of IGFBP2 has been linked to various pathological conditions, including cancer, diabetes, and metabolic disorders. Research has revealed that IGFBP2 can either inhibit or promote tumor growth depending on the cellular context, making it a potential biomarker for disease prognosis and a target for therapeutic interventions. The production of recombinant IGFBP2 protein has become important for advancing our understanding of its biological functions and interactions with IGFs and other signaling pathways. This recombinant protein is utilized in various in vitro and in vivo studies to elucidate the mechanisms by which IGFBP2 influences cell behavior and to assess its potential as a therapeutic agent. Additionally, the development of IGFBP2-targeted therapies is being explored in preclinical models, indicating its significance in the field of cancer treatment and metabolic research. Overall, the study of IGFBP2 recombinant protein is pivotal for both basic research and clinical applications, aiming to unlock new strategies for managing diseases associated with dysregulated IGF signaling.
