Analytical Data
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Gene name
PRRG1
- Application
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Alternative Names
PRRG1; PRGP1; TMG1; Transmembrane gamma-carboxyglutamic acid protein 1; Proline-rich gamma-carboxyglutamic acid protein 1; Proline-rich Gla protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14668
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Expression Region
1-218 aa
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AA Sequence
MGRVFLTGEKANSILKRYPRANGFFEEIRQGNIERECKEEFCTFEEAREAFENNEKTKEFWSTYTKAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTEGHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK
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Molecular Weight
51.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRRG1, or Proline-Arginine Rich G Protein-Coupled Receptor 1, is a protein that has gained significant attention in recent years due to its potential roles in cellular signaling and various physiological processes. Research indicates that PRRG1 is involved in the regulation of neuronal development and the modulation of synaptic activity, suggesting its importance in neurobiology. Additionally, its expression has been correlated with several pathological conditions, including cancer, where it may influence tumor progression and metastasis. The study of recombinant PRRG1 protein offers critical insights into its structure-function relationships and mechanisms of action, paving the way for therapeutic innovations. By producing PRRG1 in a recombinant system, researchers can obtain large quantities of the protein for in vitro studies, allowing for detailed investigations into its biological roles. This approach has facilitated the characterization of PRRG1's interactions with other proteins and its involvement in signaling pathways. Moreover, understanding the functional dynamics of PRRG1 is essential for exploring its potential as a biomarker for disease and a target for therapeutic intervention, particularly in neurological disorders and cancers where its dysregulation may play a crucial role. As a result, ongoing research is focused on elucidating the molecular mechanisms by which PRRG1 operates, with the ultimate aim of leveraging this knowledge for the development of novel treatment strategies.
