Analytical Data
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Gene name
PRPH2
- Application
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Alternative Names
PRPH2; PRPH; RDS; TSPAN22; Peripherin-2; Retinal degeneration slow protein; Tetraspanin-22; Tspan-22
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23942
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AA Sequence
MALLKVKFDQKKRVKLAQGLWLMNWFSVLAGIIIFSLGLFLKIGLRKRSDVMNNSESHFVPNSLIGMGVLSCVFNSLAGKICYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLMNSMGVVTLLIWLFEVTITIGLRYLQTSLDGVSNPEESESESEGWLLEKSVPETWKAFLESVKKLGKGNQVEAEGAGAGQAPEAG
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Molecular Weight
39.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRPH2, or peripherin 2, is a member of the intermediate filament protein family, primarily expressed in photoreceptor cells of the retina. It plays a crucial role in maintaining the structural integrity and functionality of photoreceptors, which are essential for vision. Mutations in the PRPH2 gene have been implicated in various retinopathies, including retinitis pigmentosa and macular degeneration, leading to progressive vision loss. Research into PRPH2 recombinant protein focuses on elucidating its biochemical properties, understanding its role in photoreceptor health, and developing potential therapeutic strategies for associated eye disorders. Studies often involve the expression of PRPH2 in heterologous systems, allowing for detailed analysis of its filamentous structure, interactions with other proteins, and responses to pathological conditions. By gaining insights into the functional dynamics of PRPH2, researchers aim to contribute to the development of gene therapy and protein replacement strategies that could ultimately improve the prognosis for patients with PRPH2-related retinal diseases. Furthermore, understanding PRPH2's interactions at a molecular level can inform the design of small molecules or other therapeutic agents that could stabilize its function or mitigate the adverse effects of mutations, thus advancing the field of retinal research and therapeutic innovation.
