Analytical Data
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基因名
SEMA4A
- Application
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别名
SEMA4A；SEMAB；SEMB；Semaphorin-4A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H3S1
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表达区间
33-683aa
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氨基酸序列
GGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGARE AILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV SYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAH KHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDAS FVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKK WTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGG TRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVG PSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHL VMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVF VGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLN SWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPH LSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFS YPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWP H
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分子量
72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEMA4A, a member of the semaphorin family, plays a pivotal role in various biological processes including neuronal development, immune response, and tumorigenesis. It functions primarily as a signaling molecule, interacting with neuropilin and plexin receptors, thereby influencing cell migration, axon guidance, and modulation of immune cell activities. Recent studies have highlighted the significance of SEMA4A in cancer biology, where its expression levels can correlate with tumor progression and metastasis. Additionally, SEMA4A has been identified as a potential biomarker for several diseases, suggesting its role in disease states beyond the nervous system. The recombinant SEMA4A protein has emerged as a valuable tool for elucidating its biological functions and therapeutic potentials, as it allows researchers to investigate its mechanisms in vitro and in vivo. By exploring the structural and functional attributes of this protein, researchers aim to unveil new pathways and targets for therapeutic intervention, particularly in oncology and autoimmune diseases. Given the evolving landscape of biomedicine, the characterization of recombinant SEMA4A could pave the way for innovative strategies in disease management and treatment.
