Analytical Data
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基因名
MLF1
- Application
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别名
MLF1；Myeloid leukemia factor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P58340
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表达区间
1-268aa
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氨基酸序列
MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK
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分子量
57.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLF1 (Myeloid Leukemia Factor 1) is a protein that has gained significant attention in the field of cancer research due to its role in hematopoiesis and its association with myeloid leukemia. Initially identified as a fusion partner in the MLF1/MLL (Mixed-Lineage Leukemia) gene rearrangement in acute myeloid leukemia (AML), MLF1 is known to function as a transcriptional regulator. Studies have shown that MLF1 can influence the differentiation and proliferation of hematopoietic stem cells, making it a crucial player in normal blood cell development. Furthermore, aberrations in MLF1 expression levels are linked to poor prognosis in AML patients, suggesting its potential as a biomarker for disease progression. Recent research has focused on the molecular mechanisms by which MLF1 modulates gene expression and its interactions with other proteins involved in hematopoietic signaling pathways. Understanding these mechanisms may contribute to the development of targeted therapies aimed at correcting MLF1-related dysregulation in leukemia. Additionally, MLF1's involvement in other malignancies has prompted investigations into its role in tumorigenesis, paving the way for broader implications in cancer biology. Overall, ongoing studies of MLF1 recombinant protein are crucial for elucidating its functional roles and potential therapeutic applications, emphasizing the need for advanced research in this promising area of study.
